Benzodiazepines

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Benzodiazepines are a class of drugs which were first developed in 1955 by Leo Sternbach and manufactured and available to be sold in 1960 by Hoffman-La Roche. Diazepam was developed soon after and it was patented in 1963 and sold by the same pharmaceutical company. It is one of the most widely used class of medications in Western countries, approved by the Medications and Healthcare Products Regulations Agency (MRHA) and included in the World Health Organisation's (WHO) list of essential medications. It is so commonly used due to its efficacy in treating a range of conditions including anxiety, insomnia, alcohol withdrawals, and some types of epilepsy, which we will go into a little later. Lorazepam is another widely used medication which has a longer half-life than some of the other benzodiazepines, making is a popular anti-anxiety medication. You can buy benzodiazepines and other anti-anxiety medication from our online pharmacy, without the need for a prescription from your GP.

It is so commonly used due to its efficacy in treating a range of conditions including anxiety, insomnia, alcohol withdrawals, and some types of epilepsy, which we will go into a little later. Lorazepam is another widely used medication which has a longer half-life than some of the other benzodiazepines, making is a popular anti-anxiety medication. You can buy benzodiazepines and other anti-anxiety medication from our online pharmacy, without the need for a prescription from your GP.

What are Benzodiazepines Used for?

As stated earlier, benzodiazepines have a range of uses. The most common use is for the treatment and management of anxiety. Anxiety can be debilitating and severely affect people's quality of life. There are different types of anxiety which include generalised anxiety disorder (GAD), panic disorder, social anxiety, and phobias (extreme irrational fears). You may have an anxiety disorder if any of the following symptoms affect you:

  • Constant worrying about many different things
  • Not being able to stop worrying when the issue has been resolved
  • Feelings of dread or like something awful is going to happen
  • Intense fear of social situations
  • Fear of embarrassing yourself or saying the wrong thing
  • Extreme fear of normal situations such as going outside
  • Experiencing panic attacks (feeling like you cannot breathe)

Worrying about an important event such as an upcoming exam or a presentation at work is not the same as having an anxiety disorder, although some people may take medication to remain calm throughout these events. Anxiety disorders are characterised by the impact they have on your day-to-day ability to function and whether or not they negatively affect your quality of life. Benzodiazepines are also used to treat sleep-onset and sleep-maintenance insomnia; however, they should only be used short-term for this purpose. Insomnia is characterised by the inability to fall asleep or the inability to remain asleep throughout the night. They can also be used for some types of epilepsy and for alcohol withdrawal symptoms. Epilepsy should be managed by a specialist neurologist however, and not self-managed, as is possible with anxiety and insomnia. Additionally, withdrawing from the physical addiction of alcohol can be very dangerous and should ideally be done in a rehabilitation centre or as an inpatient in a psychiatric hospital as there is a risk of seizures and most people need intramuscular vitamin injections.

Benzodiazepine Mechanism of Action

Benzodiazepines cause certain signals in the brain to be subdued, causing relaxation, sedation, muscle relaxation, and a reduction in the surge of electrical activity responsible for seizures. The fundamental mechanism of action of all benzodiazepines are very similar, and act on the same types of receptors. They are central nervous system depressants which are agonists for gamma amino-butyric acid-A (GABA-A) receptors. GABA-A neuronal receptors are complexes that are comprised of 5 glycoprotein subunits, of which benzodiazepines can bind to 1 of 2 receptors on each complex. When benzodiazepines bind to GABA-A receptors, they promote the production and secretion of the inhibitory neurotransmitter GABA. Neurotransmitters are chemicals in the brain which send signals. They can be either excitatory or inhibitory, and GABA is inhibitory. It is the most abundant neurotransmitter in the brain, found mainly in the cortex and limbic system. Different benzodiazepines will work slightly differently, for example they have different rates of absorption, and different elimination half-life times. Nitrazepam is rapidly absorbed into the gastrointestinal (GI) tract sand has a bioavailability of between 53% and 94% when taken orally. It has an average elimination half-life of 26 hours, which is particularly useful if you need to re-dose throughout the day, as it can remain at a consistent level in your system. Alprazolam, like other benzodiazepines, is absorbed rapidly and has a good bioavailability of around 80%, lasting for around 6 hours. As well as targeting GABA receptors, it also has a high affinity for dopamine D1 and D2 receptors, which can promote feelings of content and provide motivation. Clonazepam is lipid-soluble so crosses the blood brain barrier quickly, reaching peak concentrations after 1 to 2 hours. It has an elimination half-life of 19 to 60 hours. The elimination half-life of medications will vary depending on which type it is, as well as factors such as your metabolism, body mass index (BMI), and whether you take the medication on an empty stomach or with food.

How to Take Benzodiazepine Drugs

Before you buy benzodiazepines, it is important that you are aware of the most suitable dosage and how and when you should be taking them. Your dosing schedule will depend on the type of benzodiazepine you are taking as well as the severity of your condition. If you are taking them for GAD, you should take your first tablet in the morning when you wake up, re-dosing as necessary, ensuring to space the doses evenly throughout the day to prevent too much entering your system at once. If you are taking them for social anxiety, panic disorder, or phobias, you should take your usual dose about an hour before you know you are going into a triggering situation, or as soon as you feel the symptoms of a panic attack. If you used benzodiazepines for insomnia, then you should take your usual dose about 30 minutes to an hour before going to bed. Tablets should always be swallowed whole with a glass of water, ensuring you do not crush or chew them, otherwise this will affect the rate of absorption which could be dangerous.

Benzodiazepines vs Z Drugs

Benzodiazepines and Z drugs do have similar mechanisms of action; however, the latter is more commonly used for the treatment of insomnia and will make you drowsier. Benzodiazepines do cause sedation and relaxation; however, you will be able to stay awake and get on with your day, which would be much more difficult if you were to take Z drugs. They essentially treat two different disorders; people buy benzodiazepines for the management of anxiety and related disorders, whereas Z drugs such as zopiclone are primarily used for the management of insomnia. Both benzodiazepines and Z drugs are controlled substances, however, we have made it possible to buy sleeping pills in the UK without the prior need for a prescription.

Are Benzodiazepines Safe for Everyone?

Fortunately, yes, the majority of people over the age of 18 can buy benzodiazepines without any risk. There are a few groups of people or those with certain conditions who should avoid taking them, however. You should either avoid or consult with your GP before taking benzodiazepines if any of the following apply to you:

  • You are allergic to benzodiazepines
  • You are allergic to any of the ingredients listed in the medication
  • You have been treated for addiction in the past
  • You are also taking opiates such as morphine or codeine
  • You have serious liver or kidney problems
  • You are pregnant or breastfeeding

Benzodiazepines Have Side Effects

Unfortunately, all medications have the potential to cause side effects, and before you buy benzodiazepines it is important to be aware of them. The vast majority of side effects are mild and resolve over time without the need for medical intervention. Some of the more common side effects include:

  • Feeling lightheaded or dizzy
  • Feeling tired or drowsy
  • Loss of balance
  • Feeling weak

Do not drive or use machinery while using this medication, even if you do not feel tired or drowsy as your reaction times could be impaired and this can be dangerous. Rarely, some people experience serious side effects and if you experience any of the following, you should contact your GP and stop taking the medication:

  • Severe depression
  • Mania (feeling 'high' and not needing any sleep)
  • Hallucinations (seeing or hearing things that are not there)
  • Delusions (believing things that are not true)
  • Amnesia (not being able to remember things)
  • Jaundice (yellowing of the whites of the eyes or skin)
  • Syncope (fainting)
  • Dyspnoea (difficulty breathing)

Very rarely, people experience a severe allergic reaction which is called anaphylaxis. Symptoms of anaphylaxis include:

  • Swelling of the lips and face
  • Blotchy skin on the face and neck
  • Dyspnoea
  • Closing of the airways
  • Wheezing

It is important to note that not everyone will get blotchy skin or a rash on their face and/or neck. If you experience the above symptoms, with or without blotchy skin, you should call 999 or go to A&E immediately as this is considered a medical emergency. Some people have experienced anaphylaxis before and therefore carry an epi-pen. If you have one of these then you should inject the prescribed amount into the muscle of your upper outer thigh.

Benzodiazepine Withdrawal

Some types of medications can be habit forming and these include benzodiazepines. The more often you take the higher your tolerance will become, and you will need more to achieve the same effects. You shouldn't take them for more than 3 days per week, and if you are taking them every day, then you shouldn't take them for more than 14 days. If you do, you will most likely experience withdrawal symptoms when you stop taking them. It is a good idea to taper off so that the symptoms are not so severe. Withdrawal symptoms include the following:

  • Fever
  • Nausea and vomiting
  • Insomnia
  • Anxiety
  • Muscle aches and pains
  • Muscle spasms

Withdrawals can last anywhere from a few days to around a week, however some people experience fatigue for a number of weeks after stopping. If you are experiencing long-term withdrawal symptoms, you should seek professional medical advice. Additionally, if you have been taking them for more than 6 months and you suddenly stop, you could experience severe withdrawals including seizures and delirium, so it is important to get specialist advice and reduce your dose slowly if this applies to you.

Before You Use Benzodiazepines

Before you buy sleeping tablets online it is important to consider all the above points regarding benzodiazepines such as the potential for addiction and rebound anxiety or insomnia. There are other methods that you can try before you decide to buy benzodiazepines to manage your anxiety. Some people find other medications which reduce the physical symptoms of anxiety can be helpful. Beta-blockers such as propranolol can reduce the heart rate and lower blood pressure, which can reduce certain types of anxiety symptoms and reduce the frequency of panic attacks. Beta-blockers aren't suitable for everyone however, as they can cause bradycardia (heart rate that is too low) and hypotension (very low blood pressure). If your heart rate and blood pressure is on the low side anyway, then you shouldn't take anything that will make them any lower. There are other holistic techniques that people use to manage anxiety symptoms such as breathing exercises and doing relaxing activities such as going for walks or having a bath. There are also talking therapies which can be used alongside benzodiazepines such as cognitive behavioural therapy (CBT), which can help you cope on a long-term basis by changing the way you think about things.

Buy Benzodiazepines in the UK

Benzodiazepines are controlled Class C substances, and usually only available with a prescription from your GP. There are many reasons people cannot or do not want to go to their GP about their anxiety or to ask for specific medications such as benzodiazepines. Many GPs won't prescribe them for longer than 14 days, which obviously isn't suitable if you have a chronic condition. We believe that everyone should have the freedom to be able to order essential medications to take control of their anxiety or anxiety related conditions. That's why you can now securely buy benzodiazepines from our online UK based pharmacy. Visit www.buysleepingpills.com for a range of benzodiazepines and other anti-anxiety medications. We can offer fast and discreet shipping on all of your orders, shipped directly to your door. If you need any more information, you can visit our website where there are many ways to contact us. You can email, fill in our webform, or call our dedicated 24-hour phone line. We look forward to hearing from you!

Info Reviewed: 06 September 2022
Next Review Due: September 2023

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Robert Southwell – Apr 23, 2022
Suffer bad insomnia and cause me to be anxiety and holucations and paranoid depression and a feeling of not being safe outside and find it hard to trus

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